If you have a need for it then do it. Efe Dani does just that with a Canon 5D MKIII Vs Panasonic G7 camera low light test.
Youtube 1080p version link: https://www.youtube.com/watch?v=k4OFzsRbI60
6400/3200/1600 iso low light test. Full frame vs Micro Four Thirds(2x crop)
Same lens used both cameras. same aperture, shutter speed, white balance and standard color profile
Lens: Canon 24-70mm f/2.8L ii Usm
White Balance: 3500K
Color Profile: Standard (contrast minimum)
Shutter speed: 1/50